ea0019p304 | Steroids | SFEBES2009
Debono M
, Ghobadi C
, Rostami-Hodjegan A
, Huatan H
, Campbell MJ
, Newell-Price J
, Darzy K
, Merke DP
, Arlt W
, Ross RJ
Background: A basic tenet for hormone replacement is to replicate physiology but this is rarely if ever achieved. The adrenal glucocorticoid, cortisol, has a distinct circadian rhythm regulated by the brains central pacemaker. Loss of the cortisol circadian rhythm is associated with metabolic abnormalities, depression, fatigue and a poor health-related quality of life. Based on pharmacokinetic modelling we have developed a modified-release hydrocortisone (MR-HC) and test...